Application of CD26 and galectin-3 immunohistochemical staining in the diagnosis of thyroid carcinomas
- VernacularTitle:CD26及半乳糖凝集素3免疫组织化学染色在甲状腺癌诊断中的应用
- Author:
Nianchun PENG
;
Xiaohui GUO
;
Zhenfang YUAN
;
Yanming GAO
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Immunohistochemistry;
Antigens, CD26;
Galectin 3;
Thyroid tumor markers
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the value of CD26/DPPⅣ or galectin-3 immunohistochemical staining and their combination in the diagnosis of thyroid carcinoma. MethodsEnVision immunohistochemical technique was applied to detect the expressions of CD26/DPPⅣ and galectin-3 in thyroid tissue of 114 cases with benign or malignant thyroid tumors. ResultsCD26/DPPⅣ and galectin-3 were expressed in most of papillary carcinomas but absent in normal thyroid tissues, most of follicular carcinomas and thyroid adenomas. With CD26/DPPⅣ as means to detect papillary carcinoma, the sensitivity, specificity, diagnostic accuracy, positive predictive value, negative predictive value and Kappa index were 86.8%, 97.2%, 90.4%, 98.3%, 79.5% and 0.80 respectively,andwithgalectin-3therespective figures were 97.1%, 91.7%, 95.2%, 95.7% , 94.3% and 0.89. With CD26/DPPⅣ and gelectin-3 combined, the sensitivity, specificity, Kappa index and others in papillary carcinoma were the same as those of galectin-3 in parallel test, and the same as those of CD26/DPPⅣ in serial test. ConclusionBoth CD26/DPPⅣ and galectin-3 are reliable markers of papillary carcinoma, CD26/DPPⅣ or galectin-3 immunohistochemical staining can be used as a supplement for conventional pathological diagnostic approach to differentiate thyroid papillary carcinomas from adenomas, while the application in the diagnosis of follicular thyroid carcinoma remains to be further investigated.
