Slowing progression of chronic allograft nephropathy by conversion from cyclosporine to tacrolimus
- VernacularTitle:他克莫司替代环孢素A延缓移植肾早期发生的慢性功能丧失
- Author:
Pingxian WANG
;
Yinpu ZHANG
;
Chibing HUANG
- Publication Type:Journal Article
- Keywords:
Immunosuppressive agents;
Kidney transplantation
- From:
Chinese Journal of Organ Transplantation
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of substituting tacrolimus (FK506) for cyclosporine (CsA) on delaying the pace of renal dysfunction in patients with biopsy-proven chronic allograft nephropathy (CAN) and the molecular mechanism of the therapy.Methods From January, 1999 to May, 2002, 93 renal transplant recipients with declining graft function and biopsy-proven CAN (Grade Ⅰ), who had been taking cyclosporine (CsA) as immunosuppressive agent were studied. The patients were randomly divided into group A and group B. CsA was replaced with FK506 (1∶75) in group A that included 50 patients. Group B including the other 43 patients served as control group. All patients were followed up at least three years. Renal functions, losses of creatinine clearance rates within 3 years, incidence of acute renal graft rejection and plasma TGF-?_ 1 concentrations were compared between the two groups.Results Three years later, there were 31 patients ( 62.0 % ) with stabilized or improved graft function in group A, and 4 patients ( 9.3 % ) in group B. The difference was significant (P
