Effect of JXT on cytokines in mice infected by influenza virus(FM1)
- VernacularTitle:加味宣肺透解剂对流感病毒感染小鼠细胞因子的影响
- Author:
Bowen XU
;
Yu HAO
;
Jun WU
;
Quanying QIU
;
Qifu HUANG
- Publication Type:Journal Article
- Keywords:
Traditional Chinese Medicine;
Influenza virus;
IL-2;
TNF-?;
IL-6;
IFN-?
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the cytokine mechanism of Jiawei Xuanfei Toujie Ji(JXT)therapy to influenza infected mouse.Methods:Mice were inoculated intranasally with mouse lung-adapted influenza virus strain(FM1),and were treated with JXT. At 5th days after postinoculation were sacrificed, and IL-2,TNF-?,IL-6,IFN-? in their sera were measured with ELISA kits, their lungs sections were stained with hematoxylin and eosin.Results:Compared with model group ,the levels of IL-2 and IFN-? in JXT group were dramatically higher,and the levels of TNF-? and IL-6 were lower,and pathological effects of influenza pneumonia showed less lung injury.Conclusion:Regulative effects on cytokine may be one of the factors that JXT decrease the pathogenesis of influenza-induced acute lung injury.
