Prevention of CD4~+T cell-mediated graft-versus-host disease by CD4~+CD25~+T regulatory cells
- VernacularTitle:CD4~+CD25~+免疫调节性T细胞对CD4~+T细胞介导的移植物抗宿主病预防作用的研究
- Author:
Mei HAN
;
Guanjun WANG
- Publication Type:Journal Article
- Keywords:
CD4~+CD25~+T regulatory cells;
Bone marrow transplantation;
Graft-versus-host disease
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate if CD4~+CD25~+ regrating T cells can suppress GVHD mediated by CD4~+ T cells in murine semi-allogeneic bone marrow transplantation model and try to figure out the mechanisms evolved.Methods:C3H(H-2~k) as donors, C3H?B6(H-2~ k/b) F1(recipients) were lethally irradiated and reconstituted with antibody T cell depleted bone marrow(ATBM), and divided into 4 groups: (A)No further treatment(n=10);(B)Infused 5?10~5 C3H CD4~+T cells(CD4,n=10);(C)Infused 5?10~5 CD4~+CD25~+Treg(CD25,n=5);(D)Infused 5?10~5 CD4~+T cells plus 5?10~5 CD4~+CD25~+Treg(CD4/CD25,n=6).Results:All mice in ATBM group, CD25 group and CD4/CD25 groups survived until 60 days without any GVHD symptoms, while all mice in CD4 group died in 10 days from GVHD.Conclusion:CD4~+CD25~+Treg cells did not cause GVHD and can prevent GVHD mediated by CD4~+ T cells while co-injected with CD4~+ T cells.
