Foxp3 expression of regulatory T cells in rheumatoid arthritis
- VernacularTitle:表达Foxp3的调节性T细胞在类风湿关节炎发病中的意义
- Author:
Ping LI
;
Liqi BI
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Foxp3;
Regulatory T cell
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of Foxp3 expressing regulatory T cells in the initiation and development of rheumatoid arthritis(RA) and its correlation with clinical features of the disease.Methods:Total RNA isolated from PB in 25 RA treated patients, 25 RA untreated patients and 30 health volunteers was reversely transcribed into cDNA. The real-time-fluorescence quantitative PCR method was used to analyze the expression level of Foxp3 mRNA. The level of Anti-CCP antibody, CRP, ESR and RF of the patients were detected at the same time.Results:The level of Foxp3 mRNA from RA group was significantly lower than that of controls(P
