Effect of simvastatin on the resorption of calvaria bone induced by parathyroid hormone-related peptide in mice
- VernacularTitle:辛伐他汀对甲状旁腺素相关肽(PTHrP)诱导小鼠头盖骨骨吸收的影响
- Author:
Luyu HUANG
;
Yunyu HU
;
Huiren TAO
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Parathyroid hormone-related petide(PTHrP);
Bone resorption;
Animal model
- From:
Orthopedic Journal of China
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the effect of simvastatin on the osteoclast and the focal resorptin of calvaria bone.[Method]Animal model of calvaria bone resorption was induced by parathyroid hormone-related peptide in mice.[Result]Simvastatin on the dose of 10,20 mg/kg/d could inhibit the resorption of calvaria bone and the formation of osteoclast,while,no significant inhibition was observed on the low dose(0,5 mg/kd/d).[Conclusion]Simvastation can effectively inhibit the resorption of focal bone in mice.It may provide an important strategy in treatment of diseases involved focal bone resorption.
