EFFECTS OF METRONSDAZOLE DERIVATIVE ON MEMBRANE PERMEABILITY OF~51Cr LABELLED L_7712 CELLS
- VernacularTitle:甲硝羟乙唑衍生物对L_(7712)细胞膜通透性的影响
- Author:
Xiangshun MENG
- Publication Type:Journal Article
- Keywords:
radiosensitizer;
metronidazole derivative;
membrane permeability;
51Cr incorporation;
L7712 cells
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
This report describes the effects of a new radiosensitizer, metronidazole derivative (CM) synthesized in our laboratory, on membrane permeability of 51Cr labelled L7712 cells.It was found that CM could be incorporated into the cancer cells easily, and resulted in increased membrane permeability.Under aerobic condition, the release rate of 51Cr was increased when the cells were irradiated with more than 40 Gy Y-rays.At a dose of 0-80 Gy, the sensitization effects of CM on membrane permeability of irradiated cells were not found.
