Primary study of the tongue squamous cell carcinoma treated with targeting and continuous interstitial chemotherapy
- VernacularTitle:靶向持续性组织间化疗治疗舌鳞癌的初步观察
- Author:
Yunze XUAN
;
Jianguo ZHANG
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
Interstitial chemotherapy;
Sustaine-released;
Cisplatin;
Squamous cell carcinoma
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy and side effect of targeting and continuous interstitial chemotherapy in the treatment of tongue squamous cell carcinoma.Methods:Sustain-released cisplatin(20 mg/piece) was implanted into and around tongue squamous cell carcinoma in 10 cases,20 mg was used for the tumor at T1,40 mg for T2 and 60 mg for T3.7~10 days after implantation tumor resection was performed,the efficacy and side effect were observed.Results:The size of all tumor were reduced,50%-60% reduction was observed in 8 cases. Pathological examination of after-operation samples showed cancer cell necrosis in the center, and the degeneration and necrosis in the peripheral tissues where the drug had been implanted in.Necrosis and tissue degeneration could be seen in the metastasized lymph nodes.The side effects were local pain,hyperemia and edema in all the cases.Slight high temperature and nausea were observed in a few cases.Conclusion:The sustain-released cisplatin implanted into lesions is effective for the treatment of squamous cell carcinoma of the tongue with no severe side effects.
