Vascular endothelial growth gactor and its receptor expression in mandibular fracture healing
- VernacularTitle:下颌骨骨折愈合过程中血管内皮生长因子及其受体的表达
- Author:
Ruhui ZHANG
;
Guomin WU
;
Wenshu LIU
- Publication Type:Journal Article
- Keywords:
Fracture healing;
Vascular endothelial growth factor;
Situ hybridization
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of vascular endothelial growth factor(VEGF) and its receptor Flt1 in the process of mandibular fracture healing.Methods:The fracture models were made in the middle of the left mandible of 25 rabbits,then the specimens from the fracture site were taken 48 hours and 1,3,5 and 8 weeks after operation respectively. The expression of VEGF and Flt1 was detected by immunohistochemistry and in situ hybridization.Results:VEGF mRNA, VEGF and Flt1 were detected in many kinds of cells in the fracture site from 48 hours to 8 weeks after fracture, and high expression of VEGF and Flt1 were detected from 1 to 3 weeks after facture.Conclusions:VEGF and Flt1 are expressed through the process of fracture healing, VEGF may play important role in the process of blood vessel rebuilding after fracture.
