Survivin expression in oral squamous cell carcinoma and the effect of pingyangmycin on its expression
- VernacularTitle:Survivin在口腔鳞癌中的定量分析及平阳霉素对其表达的影响
- Author:
Zhong CHEN
;
Yuwen ZHANG
- Publication Type:Journal Article
- Keywords:
Survivin;
Mucous membrane of mouth;
Squamous carcinoma;
Apoptosis suppressor gene;
Flow cytometry;
Protein quatutive expression
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study Survivin expression in oral squamous cell carcinoma(OSCC) and the effects of pingyangmycin treatment on Survivin expression. Methods:Expression of Survivin was analyzed by flow cytometry and fluorescent indirect mark monoclonal antibody technique in 22 cases of OSCC before chemotherapy,22 cases of OSCC after chemotherapy with pingyangmycin and 8 cases of normal oral mucosa.The Survivin expression was quantified as fluorescence index(FI).Results:The FI in normal oral mucosa,OSCC before chemotherapy and OSCC after chemotherapy with pingyangmycin was 1.0?0.05,1.41?0.06 and 1.22?0.14 respectively(P
