Toxic experimental study of Antineoplastic agents-Fotemustine
- VernacularTitle:抗肿瘤药物福莫司汀粉针剂的安全性
- Author:
Min ZHANG
;
Jingyan WANG
;
Xiaoguang JI
;
Hongquan WANG
- Publication Type:Journal Article
- Keywords:
Safety evaluate;
Fotemustine;
Rabbit;
Guinea pig
- From:
Cancer Research and Clinic
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety of Fotemustine. Methods The studies had been done according to the experimental method of injection agents in pharmacodynamics guide principle on toxic test methods of application. The vascular stimulative assay of fotemustine injection on rabbit, the hemolyzation or agglutination of it in vitro, and the allergic reaction on guinea pig were performed. Results It was showed that the Fotemustine injection had no vascular irritation and injury effect on rabbit vascular endothelial cell. Compared with that of the control group, there was no difference. Conclusion No evidences of hemolyzation and aggregation on rabbit erythrocyte, and no allergic reaction on guinea pig were observed.
