Octreotide Inhibits the Growth of Hepatocellular Carcinoma Through Down-Regulation of cMet
- VernacularTitle:奥曲肽下调cMet的表达抑制肝细胞癌的生长
- Author:
Yunpeng HUA
;
Jiaming LAI
;
Lijian LIANG
;
Jiefu HUANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma Somatostatin analogue cMet
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effects and the mechanisms of octreotide(OCT) on the growth of hepatocellular carcinoma(HCC).Methods Bel7402 HCC cells were studied for proliferative ability by MTT assay,morphology by light microscopy,adhesive and invasive ability by cell adhesion and "wound strack" experiments.Immunofluorescence flow cytometry was used for study of cMet expression and cell cycle as well. Furthermore,the effects of OCT on tumor growth metastasis were investigated in nude mice with implanted HCC.The expression of cMet in implanted tumor cells was studied by immunohistochemistry.Results With OCT treatment,the proliferative ability of Bel7402 cells and cell morphology didn't change.The adhesive and invasive ability decreased compared with no OCT treatment cells(P
