Prevention of Peritoneal Adhesion Formation with Biomaterial-Degradable Polycaprolactone Film
- VernacularTitle:聚-己内酯隔离膜防止大鼠术后腹腔粘连作用的研究
- Author:
Ping ZHANG
;
Xiaohong DU
;
Bin YANG
- Publication Type:Journal Article
- Keywords:
Peritoneal adhesion Pseudomonas enzyme Polycaprolactone
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of high molecular bio-degradable film on preventing peritoneal adhesion.Methods One hundred and twenty rats were divided into control group,non-bio-degradable film group and polycaprolactone(PCL) group.Animal models of peritoneal adhesion made by operations on rats serve as control group.In the study,non-bio-degradable film and bio-degradable,namely PCL films sensitive to pseudomonas enzyme,were put into the opening of peritoneum.The effect of the films on peritoneal adhesion was examined on 1,3,7 and 30 d after operation.Results Peritoneal adhesion was found in all the rats of control group and very low in PCL group and non-bio-degradable film group.Conclusion PCL film can effectively prevent the formation of postoperative peritoneal adhesion.
