Effects of TBTCl on Immune Function of Mice
- VernacularTitle:三丁基氯化锡对小鼠免疫功能的影响
- Author:
Hehua WU
;
Zhenjun ZHANG
;
Qing CHEN
- Publication Type:Journal Article
- Keywords:
Tin;
T-lymphocytes;
Immune system
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of TBTCl on the immunity of mice. Methods The mice were randomly divided into 5 groups, namely groups of negative control, low dose (0.8 mg/kg), moderate dose (4 mg/kg), high dose (20 mg/kg) and positive control. Gavage was employed to administrate TBTCl to mice for two consecutive weeks, the number of T-lymphocyte in blood and invert ability of T-lymphocytes in spleen, hemolysin in serum, clearance exponent and viscera quotiety were determined to study the effect of TBTCl on immunity of rats. Results Compared with the control, no significantly increased T-lymphocytes were seen in low dose group, in moderate dose group the number of T-lmphocyte and the production of hemolysin increased, no obvious changes in the clearance exponent and viscera quotiety were seen. In high dose group, a significantly decreased T-lymphocytes, the clearance exponent and viscera quotiety were observed. Conclusion Low level TBTCl exposure may stimulate the immune system of mice, high exposed to TBTCl may intensively inhibit the immune system.
