Immunology state and the allograft heart survival in Echinococcus multilocularis(Em) infected rats
- VernacularTitle:泡状棘球蚴感染对大鼠免疫学状态及移植心存活的影响
- Author:
Yingmei SHAO
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
Echinococcosis,Hepatic;
T-Lymphocytes;
Eosinophils
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of echinococcus multilocularis(Em) infection on the immunology state and the allograft heart survival in the infected rats.Methods SD-to-Wistar(allograft) heart transplantation models were established to observe the influence of the disturbed(immune) system in Em infected rat on the heart graft.Sixteen healthy SD rats,8 healthy Wistar rats and 8 Em infected rats were used in the study.Animals were randomly divided into:(1) control group:SD-to-healthy Wistar rats(n=8) and(2) Em infection group:SD-to-Em infected Wistar rat(n=8).The(allograft) heart transplantation was performed by anastomosis of the donor heart of SD rats into the cervices of the Wistar rats.All the agents were administrated orally q.d.Graft samples were harvested for histopathological examination and immunohistochemical study.IL-4 and IFN-? in peripheral blood were assessed.CD4~(+),CD8~(+)and CD15Tc infiltration in the graft was detected.Results The mean survival time of the grafts in Em infected rats was 11.63?6.02 days and 6.00?0.53 days in no-infected rats respectively with the difference being significant(P
