Exogenous vascular endothelium growth factor accelerating repair of subchondral necrotic region of femoral head in rabbits
- VernacularTitle:血管内皮细胞生长因子基因转染促进股骨头软骨下坏死区修复的实验研究
- Author:
Yong JIA
;
Tongwei CHU
;
Yue ZHOU
- Publication Type:Journal Article
- Keywords:
Vascular endothelium growth factor;
Femur head necrosis;
Gene transfection
- From:
Chinese Journal of Trauma
1990;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the role of vascular endothelium growth factor (VEGF) in promoting vascular reconstruction and bone repair in the necrotic region of femoral head in rabbits. Methods The femoral head necrosis model was made by liquid nitrogen frozen. The necrotic femoral head was transfected by adenovirus human VEGF121 (Ad-hVEGF121) to observe the bone formation in subchondral necrotic region by means of histological method, measure BMD value by SPA-2 analyser and measure bone trabecular morphology by image analysis. Results Revascularization level, bone formation rate, bone quality and quantity and mineralization level in subchondral necrotic region of gene transfection group were significantly higher than the control groups that had more subchondral bone resorption compared with gene transfection group. Conclusions VEGF may have effect in promoting bone formation and revascularization in subchondral necrotic region of femoral head, indirectly protecting the necrotic bone trabecula from being absorbed and avoiding descending of subchondral mechanics function.
