The histopathologic features of rat bladder with capsaicin intravesical instillation
- VernacularTitle:辣椒辣素灌注对大鼠膀胱组织的影响
- Author:
Zhichen GUAN
;
Xianxin LI
- Publication Type:Journal Article
- Keywords:
Capsaicin;
Overactive bladder;
Histology
- From:
Chinese Journal of Urology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Morphology showed slight dilation of the vessels in the superficial part of lamina propria in the 100 ?mol/L capsaicin group.In the group treated with 2 mmol/L capsaicin,erosion of the mucosa,edema and capillary distention in the lamina propria were seen as well as focal damage to the superficial muscle near the lamina propria.This led to hematuria in the early stage.The mucosal changes started to heal after 1 week and returned to normal after 8 weeks.Conclusions In rats,intravesical capsaicin instillation at a dose of 100 ?mol/L appears to be a safe method of treatment.High doses of capsaicin may result in some reversible damages of the mucosa and inflammatory changes of the bladder.
