Preliminary observation of stem cells and olfactory ensheathing cells graft for treatment of spinal cord injury
- VernacularTitle:骨髓间充质干细胞与嗅鞘细胞联合移植治疗脊髓损伤的早期观察
- Author:
Tingbao ZHAO
;
Zhaotong LU
;
Lingyun ZHAO
- Publication Type:Journal Article
- Keywords:
Stem cells;
Olfactory ensheathing cells(OECs);
Graft;
Spinal cord injury
- From:
Orthopedic Journal of China
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigave the feasibility of commensalism of stem cells and olfactory ensheathing cells and to study the preliminary results of graft of stem cells and olfactory ensheathing cells for the treatment of spinal cord injury.[Method]Under the condition of sterility,the stem cells and olfactory ensheathing cells were collected from the embryon of induced labor for 4 to 6 months and the patients.The stem cells and olfactory ensheathing cells were cultured individually until transduced generation,then were cultured together and transplanted into the place where the spinal cord was injuried in the patient.[Result]Eight patients who had the spinal cord injury were treated with the graft of stem cells and olfactory ensheathing cells and were followed up for 1 to 6 months after the operation.One case with the T_(5~7) spinal cord injury got the recovery of superfical and deep sensation of the lower limbs.The other 7 patients had not obvious recovery.[Conclusion]There was no appearance of inhibition when the stem cells and olfactory ensheathing cells were cultured together.The united graft of the stem cells and olfactory ensheathing cells for the treatment of spinal cord injury is safe with the short-term observation.
