Expression of EDA~+ fibronectin splicing variants in the degenerated lumbar disc
- VernacularTitle:纤维粘连蛋白EDA~+片段在退变椎间盘中的表达及其意义
- Author:
Baoshan HU
;
Yue DING
;
Chunhai LI
- Publication Type:Journal Article
- Keywords:
Intervertebral disc degeneration;
Fibronectin;
Alternative splicing
- From:
Orthopedic Journal of China
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study the relationship between trauma and the lumbar disc degeneration and to detect the expression of the fibronectin splicing variants in the degenerated lumbar intervertebral disc,and study the expression of EDA.[Method]The human lumbar intervertebral disc tissues were collected to extract total RNA which was then amplified by RT-PCR technique.[Result]EDA~+ Fn of normal lumbar intervertebral disc were not expressed,whereas EDA~+ Fn of degenerated lumbar intervertebral disc were expressed abundantly.The defference between different groups has statistical significance.[Conclusion]EDA~+ Fn has very strongly expression in the lumbar degenerated intervertebral disc,and the trauma is one of prerequisite factors in the disc degenerated process probablely.
