Research advances in detection and clinical significance of circulating HPV DNA in patients with cervical cancer
- VernacularTitle:子宫颈癌患者循环HPV DNA检测及临床意义的研究进展
- Author:
Yuqi ZHOU
;
Xiaohua WU
- Publication Type:Journal Article
- Keywords:
cervical cancer;
human papillomavirus;
circulating tumor DNA;
tumor marker
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Recently,much interest has been focused on the clinical application and biology of tumor-derived DNA in the plasma/serum of cancer patients.Such interest has resulted in the demonstration of human papillomavirus(HPV) DNA in the plasma/serum of patients with cervical cancer(CC).The studies used different materials(plasma /serum),different DNA extraction methods and different primers to detect circulating free HPV DNA,so the positive rates varied from(6.9%) to 50%.The HPV DNA in the plasma/serum of patients suffering from CC most likely originates from the tumor itself,which will probably provide us with a new tool for CC monitoring after primary treatment,especially in patients in advanced stages.It is expected that this promising molecular tumor marker would soon be put into routine clinical use.
