Endocrine glands-derived-vascular endothelial growth factor and tumor
- VernacularTitle:内分泌腺源性血管内皮生长因子与肿瘤相关性的研究进展
- Author:
Pin ZHANG
;
Jun YAN
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
angiogenesis;
EG-VEGF;
VEGF;
tumor;
inhibitor
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The review is focused on the development and recent research of the first tissue-specific angiogenic molecule,endocrine gland-derived vascular endothelial growth factor(EG-VEGF).It has been found that EG-VEGF only targeted on steroidgenic endocrine organs or cells through G-protein coupled receptor,the phosphorylation of G-protein coupled receptor could activate mitogen-activated protein kinase p44/42 and phosphatidylinositol-3 kinase(PI3K) pathways signal transdution.There are many reports that believes MAPK and PI3K is involved in the regulation of proliferation,migration,survival of endothelial cells and tumor angiogenesis,so EG-VEGF may serve as a potential target for antiangiogenic therapy of cancer in the future.
