Study on the prediction of early liver metastasis of colorectal tumor by detection of CK20mRNA、CD44v6 and PCNA
- VernacularTitle:CK20mRNA、CD44v6和PCNA对大肠癌早期肝转移预测的研究
- Author:
Lei CHEN
;
Dongfen ZHOU
;
Huizhong LIN
;
Xiaochuan LI
;
Hong LI
- Publication Type:Journal Article
- Keywords:
CK20mRNA ? CD44v6 ? Proliferating cell nuclear antigen ? Colonlc neoplasms ? Rectal neoplasms ? Neeplasm metastsis ? Liver
- From:
Chinese Journal of Current Advances in General Surgery
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To obtain some effective objective markers used to predict the early liver metastasis of colorectal tumor,the relationship of liver metastasis of colorectal tumor with associate detection three markers such as CK20mRNA、CD44V6 and PCNA was studied. Methods:The expression of CK20mRNA in portal venous blood from 30 colorectal cancer patients was detected by fluorescent quarto RT-PCR,and the results of CD44V6 and PCNA in colorectal cancer tissue were determined by means of immunohistochemistry, and then compared with control groups through statistics analysis. Results:The rate of positive expression of CK20mRNA in colorectal cancer patients' portal venous blood was obviously superior to the level of benign pathological changes controls(P
