Mechanism of the change of blood pressure in rat model of high-fat diet-induced obesity
- VernacularTitle:饮食结构变化诱导SD大鼠肥胖及血压变化的机制
- Author:
Xiangling WANG
;
Aiqun MA
;
Hongyan TIAN
- Publication Type:Journal Article
- Keywords:
obesity;
blood pressure;
insulin resistance;
free fatty acids
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of high-fat diet on blood pressure and metabolism in Sprague-Dawley(SD) rats and its mechanism.Methods Forty male SD rats were randomly divided into 4 groups which were fed with a diet containing 53% calorie as fat(HF) or a normal diet(ND) for 5 or 10 weeks.Systolic blood pressure(SBP),body weight,abdominal adipose tissue,blood lipids,fasting insulin(FINS),and fasting plasma glucose(FPG) were measured after 5 and 10 weeks respectively.Results SBP of HF groups were higher than that of ND groups [HF5 vs.ND5,(105.506?4.634)mmHg vs.(100.060?4.773)mmHg,P
