Effect of hyperoxia liquid preconditioning on malondialdehyde and super oxide dismutase during valve replacement with cardiopulmonary bypass
- VernacularTitle:高氧液预处理对心脏瓣膜置换术患者血浆丙二醛和超氧化物歧化酶的影响
- Author:
Jun YU
;
Guixia JING
- Publication Type:Journal Article
- Keywords:
hyperoxia liquid;
preconditioning;
cardiopulmonary bypass;
myocardial protection;
malondialdehyde;
super oxide dismutase
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the cardioprotective effects of hyperoxia liquid by comparing the changes of blood concentrations of malondialdehyde(MDA)and super oxide dismutase(SOD)in mechanical heart valve replacement.Methods Thirty patients required mechanical heart valve replacement were randomly divided into hyperoxia liquid group(Group HL) and control group 15 cases in each.From the start of skin incision(T_(0)) to(10min) after CPB,patients received 10mL/kg Ringer's injection(control group) and 10mL/kg hyperoxia liquid(Group HL) seperately.The central venous blood samples,which were collected in both groups respectively at skin incision(T_(0)),1h after start of CPB(T_1),2h(T_2) and 24h(T_3) after aorta off-clamping,were used to test the blood concentrations of SOD and MDA.Also a series of clinical data were recorded,such as the rate of heart automatic rebeat after aorta off-clamping,ventricular arrhythmia,usage of dopamine in operation and postoperation.(Results)In both groups,the blood concentrations of MDA and SOD were all within normal range before operation.MDA level at T_(2) was lower in Group HL than that in control(P
