Loss of hetrozygosity of p53 gene and p53 gene mutation in esophageal squamous cell carcinoma
- VernacularTitle:食管鳞状细胞癌p53基因杂合性缺失和基因突变的相关研究
- Author:
Xuanqin YANG
;
Quanhong WANG
;
Guang LI
- Publication Type:Journal Article
- Keywords:
Loss of hetrozygosity;
p53 gene;
Gene mutation;
Esophageal squamous cell carcinoma
- From:
Cancer Research and Clinic
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). The positive rate was 81.0 %(17/21) in those with lymph node metastasis vs 48.6 %(17/35) in those without lymph node metastasis. The 3 year survival rate with p53 protein expression was significantly lower than those without p53 protein expression. [46.4 %(13/28) and 73.9 %(17/23) respectively]. The LOH rate of p53 gene in ESCC was 80.5 %(33/41), which had no obvious correlation with Age,Sex, Family history and lymph node metastasis, but had obvious correlation with the 3 year survival rate(P
