The influence of EBV infection on p53 expression in gastric carcinoma patients from Tangshan area
- VernacularTitle:唐山地区胃癌患者EB病毒感染与p53基因表达的关系
- Author:
Shuying LI
;
Jinlan GAO
;
Qingan XIA
;
Tianji ZHOU
- Publication Type:Journal Article
- Keywords:
EBV infection;
p53 expression;
Gastric carcinoma
- From:
Cancer Research and Clinic
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of EBV infection on the expression of tumor suppressor gene p53. Methods EBER1 in 217 cases of gastric carcinoma were detected with in situ hybridization. Then, EBV positive and negative cases were selected for analysis of the expression of p53 by immunohistochemistry. Results In 217 cases of gastric carcinoma, there were 23 cases with EBER1 positive. The average area (AA), mean absorbency and integral absorbency of p53 expression were higher in EBV positive gastric carcinoma than those in EBV negative. Conclusions EBV infection of gastric carcinoma is closely related to the expression of p53 in this study.
