The efficacy of microbubbles augmentation thrombolysis using low-frequency ultrasound: an in vitro study
- VernacularTitle:低频超声介导微泡造影剂对体外血栓的助溶作用
- Author:
Yali XU
;
Zheng LIU
;
Yunhua GAO
;
Kaibin TAN
- Publication Type:Journal Article
- Keywords:
Ultrasonic therapy;
Contrast media;
Thrombolytic therapy
- From:Chinese Journal of Ultrasonography
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To promote in vitro tissue-plasminogen activator(t-PA)thrombolysis by using microbubbles augmented low frequency ultrasound(US) insonication.Two kinds of microbubbles,albumin-coated vs.lipid-coated were compared.Methods Human blood clot weighted 200～300 mg was made from of 0.8 ml fresh blood.Twenty kHz ultrasound,lipid and albumin-coated microbubbles were applied to separate clots groups with or without t-PA administration.The clots before and after processing were weighed and then the clot dissolution ratios were calculated.Results The simple ultrasound group and the basic t-PA group dissolved((24.72)?(4.83))% and((35.66)?(3.34))% of the clots,respectively.The clot dissolution ratio rised to((42.06)?(4.20))% when coordinated US and t-PA(P(0.05)).Conclusions The in vitro US augmentation of t-PA thrombolysis can be significantly promoted by introduction of microbubbles.But there is no significant thrombolysis difference between albumin and lipid-coated microbubbles.
