Tumor necrosis factor-? gene polymorphism is related to thyroid-associated ophthalmopathy
- VernacularTitle:肿瘤坏死因子?基因多态性与甲状腺相关性眼病相关
- Author:
Yingxue WANG
;
Shengli YAN
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Thyroid associated ophthalmopathy;
Autoimmune thyroid diseases;
Tumor necrosis factor-?;
Polymorphism (Genetics)
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The -1031T/C polymorphism of tumor necrosis factor-? (TNF-?) gene was determined by PCR-RFLP in 54 patients with thyroid-associated ophthalmorpathy (TAO), 60 patients with autoimmune thyroid disease (AITD) without ophthalmopathy and 76 healthy subjects. The results showed that the frequencies of TC+CC genotype and C allele in TAO group, especially in male patients, were significantly higher than those in the other two groups (both P
