Experimental Study on Detection of Acute Cerebral Ischemia with Multislice CT Perfusion Imaging
- VernacularTitle:多排CT灌注成像诊断急性脑缺血的实验研究
- Author:
Chaoxiang YANG
;
Liang GUO
;
Yi DING
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
tomography,X-ray computed;
perfusion imaging;
experiment
- From:
Journal of Practical Radiology
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ability of the four-slice perfusion maps derived by multislice CT(MSCT)perfusion imaging (CTPI) to detect ischemic lesion in rabbit models with the middle cerebral artery occlusion(MCAO). Methods Sequential dynamic CT studies were performed at four slices in 2 control rabbits and another 8 with MCAO. The volume of critically ischemic lesions on CTPI maps at 1st,2nd and 3rd hour after operation and the volume of infarction measured by postmortem 2,3,5- triphenyltetrazolium chloride (TTC) staining were analyzed by analysis of variance with random blocks design and linear correlation. Results In 6 of 8 animals of the ischemia group, critically ischemia or infarction was visible on perfusion maps and TTC-staining,while appearing negative in 2 control rabbits. In four-slice CTPI maps, lesions were visualized in 2 of 4 slices at least. The results of analysis of variance demonstrated that the intergroup differences were discovered between 1st , 2nd and 3rd hour after operation, and between MTT map and other CTPI maps (P
