Expression of insulin-like growth factor 1 in oral submucous fibrosis tissue
- VernacularTitle:胰岛素样生长因子在口腔黏膜下纤维性变组织中的表达
- Author:
Xia LI
;
Tianyou LING
- Publication Type:Journal Article
- Keywords:
Oral submucous fibrosis;
Insulin-like growth factor 1;
In situ hybridization technique
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of insulin-like growth factor 1(IGF-1) in the pathogenesis of oral submucous fibrosis(OSF).Methods:IGF-1 mRNA in 27 OSF tissues and 9 normal tissues were detected by the in situ hybridization technique.Results:There were expression of IGF-1 mRNA in keratinocytes of all the 8 cases of early stage OSF and 7 of the 19 cases of middle-late stage OSF.No expression of IGF-1 mRNA was detected in keratinocytes of nomal tissue.There were no significant difference between OSF tissues and normal tissues in the expression of IGF-1 mRNA in fibroblasts.IGF-1 mRNA expression in endothelial cells were found in 5 cases of middle-late stage.Conclusion:IGF-1 might be secreted by keratinocytes and may play important role in the pathogenesis of OSF.
