Expressions of focal adhesion kinase and paxillin in human scar tissues
- VernacularTitle:人瘢痕组织中黏着斑激酶及桩蛋白的变化
- Author:
Fusheng ZHANG
;
Shuliang LU
;
Fei SONG
- Publication Type:Journal Article
- Keywords:
Cicatrix;
Signal transduction;
Extracellular matrix;
Focal adhesion kinase
- From:
Chinese Journal of Trauma
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression changes of paxillin and focal adhesion kinase(FAK) in scar tissues at different periods.Methods The expressions of paxillin and FAK of scar tissue samples from 30 babies at age of 3-12 months were detected by means of immunohistochemistry.Results The expressions of paxillin and FAK in the scar tissues at the 3th and 6th months were increased more significantly than that in normal skin tissues.Whereas,there was no significant difference upon the expressions of paxillin and FAK in the scar tissues at the 12th week compared with normal skin tissues.Conclusion Focal adhesion varies with change of composition,structures and mechanical properties of extracellular matrix(ECM) and with different intracellular framework.Different signal transmissions of ECM,integrin and focal adhesion compound may result in different changes of cellular function.
