The expression and significance of transforming growth factor-?,its receptor and proliferation-related antigen Ki-67 in nephroblastoma
- VernacularTitle:转化生长因子?及表皮生长因子受体与Ki-67在肾母细胞瘤组织中的表达及意义
- Author:
Jiaxiang WANG
;
Shuaijun DONG
;
Qiuliang LIU
;
Yingzhong FAN
- Publication Type:Journal Article
- Keywords:
Nephroblastoma;
Transforming growth factor-?;
Epidermal growth factor receptor;
Proliferation-related antigen Ki-67;
Immunohistochemistry
- From:
Chinese Journal of Urology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of transforming growth factor-?(TGF-?),epidermal growth factor receptor (EGFR) and proliferation-related antigen Ki-67 in nephroblastoma. Methods Immunohistochemistry method was used to detect the expression of TGF-?,EGFR and Ki-67 in 8 cases of normal kidney,35 cases of nephroblastoma and 14 cases of the tissues adjacent to nephroblastoma.The differences of their expression were compared among the 3 kinds of tissues and different pathologic characteristics of nephroblastoma. Results The expression rates of TGF-?,EGFR and Ki-67 in nephroblastoma were 51.4%(18/35),62.9%(22/35) and 68.6%(24/35),respectively,which were significantly higher than those in the tissues adjacent to nephroblastoma and the normal kidney;the differences were significant (P0.05);but positive relationship was found between the expression and clinical stages (P
