Study on expression and clinical significance of uPAR and VEGF-C in ovarian cancer
- VernacularTitle:尿激酶型纤溶酶原激活物受体,血管内皮生长因子C在卵巢癌中的表达与临床意义
- Author:
Yuyang ZHANG
;
Cixia SHUAI
;
Feiyun ZHENG
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Ovarian serous adenocystic cancer;
uPAR;
Vascular endothelial growth factor C;
Immunohistochemistry
- From:China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:urokinase-typeplasminoogen activator receptor(uPAR) plays important roles in terms of fibrolysis in tissue,cell adhering prolifration and signal transduction uPAR can the detected in both cancer and matrix cells.It has been reorted that uPAR is associated with invasion and metastasis of cancer cells.This paper is to study the effects of the gene expression of uPAR and VEGF-C on onco-genesis and progression of ovarian cancer.Methods:The expression of uPAR gene protein and VEGF-C were examined immunohistochemically in 58 cases of ovarian serous cystadenocarcinoma,10 cases of borderline serous cystadenomas and 13 cases of serous cystadenocarcinoma.The relationships between the results and pathological features were studied.Results:① The expressions of uPAR in benign and malignant tumors were different significantly(P
