Animal study on the feasibility of regional gastroduodenal artery or splenic artery ligation followed by regional intraarterial perfusion of pancreas with 5-FU
- VernacularTitle:胰腺区域血管结染后动脉灌注化疗可行性的动物实验研究
- Author:
Huajie ZHANG
;
Yunshu DING
;
Yongguo LI
;
Wei LIU
- Publication Type:Journal Article
- Keywords:
pancreas;
gastroduodenal artery;
splenic artery;
regional chemotherapy;
5-FU;
pig
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and Purpose:Pancreatic cancer is malignant tumor of the digestive tract with poor prognosis and is not sensitive to conventional chemotherapy.This study investigates the safety and feasibility of regional arterial ligation followed by intra-arterial perfusion chemotherapy in 14 pigs divided into groups A,B and C.Methods:14 pigs were divided into 3 groups.Group A(n=5) underwent gastroduodenal artery ligation and catheterization through the right gastroepiploic artery.Group B(n=5) underwent splenic artery ligation and catheterization.Group C(n=4) underwent left periotic vein puncture.5-FU(20mg/kg) was perfused into these catheters in 60 min.Blood samples and pancreatic tissue were obtained for the purposes of the determination of drug concentration and pathological diagnosis.Results:At 80 min and 100 min the drug concentration in portal vein of group A and group B were higher than those of group C(P
