Microtubule-destabilizing protein stathmin—a new target for gene therapy of cancer
- VernacularTitle:微管不稳定蛋白Stathm in——肿瘤基因治疗新靶点
- Author:
Jing LIANG
;
Yan LI
- Publication Type:Journal Article
- Keywords:
Stathmin;
mitotic spindle;
microtubule depolymerization;
cancer therapy
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Stathmin is a novel member of microtubule-destabilizing proteins that play a critical role in the regulation of the dynamic equilibrium of microtubules during different phases of the cell cycle.The overexpression of stathmin was found in different type of cancer.Inhibition of stathmin expression in malignant cells may interfere with their orderly progression through the cell cycle.Overexpression of stathmin can affect the action of antimicrotuble drugs by markedly decreasing binding of paclitaxel,and increasing binding of Vinca alkaloids.In addition,stathmin provides an attractive molecular target for cancer therapy.It may be possible to combine adenovirus-mediated anti-stathmin ribozyme therapy with a chemotherapeutic agent such as taxol to obtain a more potent antiproliferative and antitumor effect.
