Effect of Extracorporeal Liver Alloperfusion in Treatment of Acute Liver Failure in Pigs
- VernacularTitle:急性肝功能衰竭猪应用同种体外肝脏灌注技术支持的实验研究
- Author:
Guoxun LI
;
Yongheng ZHAO
;
Ximo WANG
;
Gang LONG
;
Zhongkui JIN
;
Jinggang ZHU
;
Jialin WANG
;
Honglei WANG
;
Ping WANG
;
Gang LI
;
Yu ZHANG
;
Jin GONG
;
Tao JIANG
;
Shi CHEN
- Publication Type:Journal Article
- Keywords:
Acute liver failure Extracorporeal liver perfusion
- From:
Chinese Journal of Bases and Clinics in General Surgery
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility and curative effect of extracorporeal liver perfusion (ECLP) in treatment of acute liver failure (ALF) in pigs. Methods The experiments were carried out in healthy pigs (weight 20-30 kg) under general anesthesia. All of the pigs were randomly divided into 3 groups. ALF model was established by liver blood supply obstructing and portal-systemic shunting. ALF group (n=5): ALF pigs were killed 8 h after establishing. ALF+ECLP group (n=5): ALF pigs were perfused with ECLP for 4 h and killed 8 h after establishing. Normal liver+ECLP group (n=4): normal pigs were dealt with just as ALF+ECLP group. The data of PT, AST, TNF, blood ammonia were collected in all groups. Pathologic changes in liver and brain were detected. Results The levels of PT, AST, TNF, blood ammonia, RBC and HCT in the ALF+ECLP group were lower than those in the ALF group (P
