The association between the inducible costimulatory molecules,CD_(28),CD_(24) gene polymorphisms and multiple sclerosis
- VernacularTitle:可诱导协同刺激分子、CD_(28)、CD_(24)基因多态性与多发性硬化的相关性
- Author:
Yuzhen CUI
;
Bo XIAO
;
Wenbing ZHOU
;
Aiyu LIN
;
Huan YANG
- Publication Type:Journal Article
- Keywords:
Antigens, differentiation, T-lymphocyte;
Multiple sclerosis;
Polymorphism, restriction fragment length
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the gene polymorphism of the inducible costimulatory molecules (ICOS),CD_(28),CD_(24) and susceptibility to multiple sclerosis(MS). Methods 83 patients with MS and 110 controls selected from healthy individuals and hospital staff in Chinese Han people with non-autoimmune diseases were studied by detecting genotype of the 3 genes using PCR-RFLP method. Results The frequency of ICOS-2394 TT genotypes was significantly higher in MS patients than in controls (MS 33.7%vs controls 10.9%, P
