Effect of Intracellular Glutathione in Relieving the Cytotoxicity Induced by Arsenic
- VernacularTitle:细胞内谷胱甘肽对砷细胞毒性的保护作用
- Author:
Xiance SUN
;
Shan LIU
;
Guifan SUN
- Publication Type:Journal Article
- Keywords:
Sodium arsenite;
HaCaT;
Glutathione
- From:
Journal of Environment and Health
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of cellular glutathione (GSH) in relieving the cytotoxicity induced by arsenic on HaCaT. Methods The HaCaT cells were pre-treated with N-acetylcysteine (NAC) and L-buthionine-[S'R]-sulfoximine (BSO) for 24 h, then treated with sodium arsenite (NaAsO2) by adding it into the medium for 24 h. Alarmarblue assay was used to detect the proliferation of the cells. Results The reduction rate of Alarmarblue increased when the HaCaT cells were treated with 0.001-10.000 ?mol/L of NaAsO2 alone (P
