Clinical study of occasio for antibiotic prophylaxis in hip arthroplasty surgery
- VernacularTitle:人工髋关节置换术预防性抗生素应用时机的临床研究
- Author:
Xu CAI
;
Yi FANG
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
Hip arthroplasty;
Antibiotics;
Prophylaxis;
Serum bactericidalactivity
- From:
Orthopedic Journal of China
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study the best time for infusing antibiotics as prophylaxis against infection in hip arthroplasty.[Method]Ninty cases of hip arthroplasty were divided into 6 groups randomly with 15 cases each.Ampicillin(UNASYN,1.5g) and cefuroxime axetil(Zinacef, 2.0g) was administered by intravenous infusion respectively one day or one hour before operation or 30 minutes after the operation began.Blood samples from peripheral vein,cancellous bone of acetabulum when reaming,medullary canal of femur when rasping and catheter right after the operation were harvested.Serum Bactericidal Activities(SBAs) were determined by minim dilution technique and were compared between the groups.[Result]SBAs of UNASYN and Zinacef are similar to the bacteria most commonly causing infection after prosthesis implantation such as staphylococcus.Percentage at SBA≥1:8 of UNASYN and Zinacef is significantly more at the beginning of operation and when reaming acetabulum than the other groups(P
