The establishment of multiple clinical processes on experimental allergic encephalomyelitis model of Wistar rat
- VernacularTitle:Wistar大鼠多病程实验性变态反应性脑脊髓炎的模型建立
- Author:
Mei DONG
;
Ruichun LIU
;
Li GUO
;
Chunyan LI
- Publication Type:Journal Article
- Keywords:
Experimental allergic encephalomyelitis;
Multiple sclerosis;
Animal model
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate establishing the multiple clinical processes model and pathological characteristics of EAE model,and to provide the experimental value for reseaching MS. Methods:The animal model was established in Wistar rat by immunization with complete Freund adjuvant and GPSCH, the pathological changes of EAE were studied with the aid of light microscopy. Results : We can divide the EAE into five types by pathological changes and clinical manifestation: acute EAE, relapsing-remitting EAE, persistent progress EAE,benigh form EAE and delitescence EAE. Every type mainly showed congestion and inflammatory cuff of small blood vessels,disintegration and disappear of myelin sheath and degeneration of neurons,especially in spinal cord. Conclusion:Multiple clinical processes on EAE model of Wistar rat were established for the first time.it is an ideal animal model in studying MS.
