Clinical biology value of p53 overexpression in Chinese breast cancer by Meta analysis
- VernacularTitle:中国乳腺癌患者p53表达临床生物学意义的Meta分析
- Author:
Changzheng DU
;
Huiping LI
;
Liwen MA
- Publication Type:Journal Article
- Keywords:
p53;
Chinese breast cancer patients;
Meta analysis
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To find out the clinical biology value of p53 overexpression on Chinese breast cancer by Meta analysis. Methods:Reviewed all the published studies during the recent 10 years regarding p53 and breast cancer, and used standard techniques of Meta-analysis to combine the results of these studies to produce a more precise estimate of the prognostic significance of p53 mutations.Results:the mean of p53 positive express was 45%,95% confidence interval (43-47)%:, p53 positive was related with node metastasis, recurrence after surgery, over survival, tumor size and nuclear grade, but not related with age and pathology type, p53 was a special and sensitive prognostic factor for breast cancer.Conclusions:p53 can be an independent molecular marker to definitive prognostic of breast cancer, and possibly can be a reliable marker for choice of standard and individulized therapy.
