Correlation between Akt phosphorylation and loss of PTEN protein expression in non-small-cell lung cancer
- VernacularTitle:磷酸化Akt和PTEN在非小细胞肺癌组织中的表达及其相关性
- Author:
Jianmin TANG
;
Quanying HE
;
Xiujun CHANG
- Publication Type:Journal Article
- Keywords:
non-small-cell lung cancer;
Akt;
phosphatase and tensin homologue deleted on chromosome 10(PTEN);
immunohistochemistry;
cell cycle regulation
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To clarify roles of overexpression of phosphorylated Akt(p-Akt) and loss of phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in biological behavior of non-small-cell lung cancer(NSCLC). Methods:Immunohistochemical staining was used to determine the expression of p-Akt and PTEN in 20 cases of normal lung tissues and 102 patients with NSCLC.Results:Negative p-Akt expression and positive PTEN expression were found in normal lung tissues, while the positive incidences of p-Akt expresssion and loss of incidences of PTEN expresssion in NSCLC were 41.2% (42/102) and 46.1% (47/102)respectivtly.The overexpression of p-Akt and loss of PTEN expression were correlated to degree of differention of cancer, metastasis(including lymph node), and clinical stages. A significant negative correlation was observed between expression of p-Akt and PTEN(Phi r=-0.425,P
