Comparison between urinary cytokeratin test and voided urine cytology for detection of bladder cancer
- VernacularTitle:尿细胞角蛋白检测与尿脱落细胞学检查在膀胱癌诊断中的价值
- Author:
Rumin WEN
;
Song XUE
;
Ping MA
- Publication Type:Journal Article
- Keywords:
bladder cancer;
keratin;
urine cytology;
diagnosis
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To compare the sensitivity and specificity of urinary cytokeratin test with voided urine cytology in detection of bladder cancer and to evaluate their clinical values. Methods:For 136 patients suspected to have bladder cancer urinary concentrations cytokeratin 8 and 18 and cytology were conducted in the same voided urine samples. Of them 87 patients with bladder transitional cell carcinoma were confirmed histologically The sensitivity and specificity of urinary cytokeratin and urine cytology were analyzed. 49 patients without bladder cancer were selected as control.Results:The overall sensitivity and specificity of urinary cytokeratin test were 70.1% and 73.3%,respctively ,those of urine cytology were (42.5%) and 83.7%, respectively, there was no significant difference between the specificity of urine cytology and that of urinary cytokeratin test ;however, urinary cytokeratin was significantly more sensitive than urine cytology in detection of any stages and grades of bladder cancer (P
