Mobilization and collection of peripheral blood stem cells by using rhG-CSF in healthy donors
- VernacularTitle:健康供者外周血造血干细胞动员采集最佳时机的探讨
- Author:
Lin WANG
;
Keshan SHI
;
Zhiming BAI
;
Xiaoxia CHEN
;
Zhiming WANG
;
Xiansheng LUO
;
Chumiao LIU
;
Lili HE
;
Qin WU
;
Rongxiang FU
;
Ziying HUANG
;
Shumei HUANG
;
Haimei HUANG
;
Liqiong LI
- Publication Type:Journal Article
- Keywords:
Mobilization;
Collection;
Peripheral blood stem cells;
Transplantation
- From:
Cancer Research and Clinic
2005;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of mobilization and collection's time of peripheral blood stem cells(PBSC) from 8 cases of healthy donors. Methods The 10 donors were studied by self-control design.The number of aphereses was two times every donors. Healthy donors received rhG-CSF according to two different PBSC collection starting time: group 1:PBSC collection was starts 2 hours(2 h) after the fourth day or the fifth day of rhG-CSF. group 2:PBSC collection was starts 4 hours(4 h) after the fourth day or the fifth day of rhG-CSF.(The first dose of rhG-CSF was given on day 1, considering day 0 as the day before starting mobilization). In this study we have compared with two groups of apheresis product. Results The MNC count was significantly higher for donors 4 h collection (groups 2) then 2 h. ( groups 1)(P
