Establishment of rabbit liver cancer model by implanting VX2 tumor under ultrasound guidance and its sonographical evaluation
- VernacularTitle:超声引导下经皮兔肝内VX2肿瘤接种方法初探及其超声评价
- Author:
Lei FENG
;
Qiujin XIAO
;
Yang WANG
;
Yaqi DUAN
;
Ping LIANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Liver neoplasms,experimental
- From:
Chinese Journal of Ultrasonography
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the establishment of rabbit model with VX2 liver tumor and assess sonographical value in monitoring the tumor growth.Methods Fifteen New Zealand white rabbits were implanted with VX2 tumor in two liver lobes under ultrasound guidance percutaneously.Ultrasound examinations were performed at twenty days and thirty-six days after implantation.At the same time exploratory laparotomy was performed.Results Among 30 implanted tumors of 15 rabbits,16(53%) tumors were successfully implanted with few complications.It took 15 to 40 minutes to implant tumors in one rabbit.Implantation rates of left lobe and right lobe were 53% and 50% respectively,and there was no significant difference.Ultrasound examination could monitor tumor growth well.Conclusions After the improvement,the establishment of model was easier,less time-consuming,minimally invasive and caused few complications than other implantation methods.Serial ultrasound examinations should be performed in monitoring the tumor growth.
