Setting up of Intraluminal Thread Approach in Making Focal Cerebral Ischemia/Reperfusion Model in Rabbit and the Evaluation of Image Features
- VernacularTitle:线栓法兔局灶性脑缺血/再灌注模型的的制作及影像学评价
- Author:
Xiuchuan JIA
;
Huaijun LIU
;
Hongyan LV
- Publication Type:Journal Article
- Keywords:
ischemia;
reperfusion;
animal model;
rabbit
- From:
Journal of Practical Radiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a stable model of intraluminal thread approach in making focal cerebral ischemia/reperfusion modelin rabbit.Methods Forty New Zealand white rabbits were randomly divided into three groups:A,B,and C.Angiography of ICA wasperformed in group A(n=5). Control group B(n=5) was sham-operated.In group C(n=30),the focal cerebral ischemia/reperfusionmodel was made by inserting a wire ( d=0.45 mm ) into MCA through ICA and CCA directly and pulling it out 3 hours later . MRI andneurological deficit score were used to evaluate the effectiveness of models.Results Angiography could show the course and bifurcation of ICA clearly.22 models were successful.The pathological changes were shown on MRI.The neurological deficit score (reperfusion 1 h) were 2.8?0.45.Conclusion The focal cerebral ischemia/reperfusion model made by inserting a wire(d=0.45 mm) into MCA through ICA and CCA directly and pulling it out 3 hours later was stable and fit for imaging research.
