The Relationship Between p16 Expression and Angiogenesis as well as Value of CT Enhancment in Peripheral Lung Cancer
- VernacularTitle:周围型肺癌p16表达与血管生成及CT增强的关系
- Author:
Xiuhong SHAN
;
Jinxu ZHENG
;
Weibin PENG
;
Weibin SUN
- Publication Type:Journal Article
- Keywords:
lung;
pulmonary carcinoma;
neoangiogenesis;
tomography,X-ray computed
- From:
Journal of Practical Radiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between expression of p16 and tumor angiogenesis as well as value of CT enhancement in peripheral lung cancer. Methods twenty-three patients with peripheral lung cancer were examed with dynamic CT scan before surgery.The MVD、protein expression of VEGF and p16 were measured immunohistochemically on speciments of resected tumors.Results There were negative correlation tendency between expressions of p16 and VEGF,but the difference were no significant.During the course of delaying 30 s from injecting contrast dose,the relating coefficient was the highest between enhanced CT value and MVD,P=0.9364.The mean value of MVD and CT enhancement in the course of delaying 30 s in p16 negative expression group were higher than that in the group of p16 positive expression with no significant.Conclusion p16 negative expression may improve angiogenesis in peripheral lung cancer.
