The Effect of Sodium Fluoride on Tumor Markers of Human Embryonic Bronchial Epithelium Cells
- VernacularTitle:氟化钠对人胚支气管上皮细胞肿瘤标志物的影响
- Author:
Daoxin MA
;
Chunsheng LIU
;
Jie LI
- Publication Type:Journal Article
- Keywords:
Sodium fluoride;
Human embryonic bronchial epithelial cell;
Tumor markers
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of sodium fluoride(NaF) on the tumor markers of human embryonic bronchial epithelium (HEBE) cells.Methods HEBE cells were collected from the human abortive fetues.The cells were exposed to NaF of several concentrations for 36 h.After rinsed,the cells were incubated for 36 h again.The NaF toxicity to HEBE cells was detected using MTT method.The supernatant was collected and the lung tumor markers were detected using ELISA method.Results NaF was toxic to the HEBE cells,and the toxicity was increased with the NaF doses.There were few survival HEBE cells at 6 mmol/L NaF.The tumor markers in both of the control and experiment groups were very low,and no significant difference had been seen between them.Conclusion NaF may damage HEBE cells,but may not influence the tumor markers of HEBE cells.
