Change of Bone ?-Carboxyglutamic Acid Containing Protein in the Serum of Rats at the Initial Stage of Skeletal Fluorosis Caused by Fluoride in Coal
- VernacularTitle:燃煤型高氟玉米氟骨症早期大鼠血清骨钙素的变化
- Author:
Chun XIE
;
Hua ZHANG
;
Maojuan YU
- Publication Type:Journal Article
- Keywords:
Fluoride;
Fluorosis,dental;
Coal-burning fluorosis;
Skeletal fluorosis;
Bone ?-carboxyglutamic acid containing protein
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of bone ?-carboxyglutamic acid containing protein(BGP) in serum of rats at the initial stage of skeletal fluorosis caused by fluoride in coal.Methods SD rats were randomly divided into 6 groups (the number of female and male in each group was the same respectively):the control group,the low-dose fluoride group,the middle-dose fluoride added nutrition group,the middle-dose fluoride group,the high-dose fluoride added nutrition group,the high-dose fluoride group.All rats in the experimental groups were fed on the corn collected from the prevalent areas and contained different contents of fluoride respectively for 90-100 days.Content of fluoride in the urine,bone,kidney,BGP in serum,bone mineral density (BMD)and calcium in the bone and urine were determined.Results The fluorosis of the rats became more serious as fluoride intake increased.On the condition of same fluoride intake,the fluorosis could be relieved if nutrients added.BGP in serum of rats in each experimental groups had a increase trend,at the earlier stage,BGP of the high-dose group was higher than that of the control group (P
