Toxicity of a Heavy Metal Removal Engineering Strain to Mice
- VernacularTitle:去除重金属的工程菌对小鼠的毒性
- Author:
Xianyan LU
;
Hua YIN
;
Hui PENG
- Publication Type:Journal Article
- Keywords:
Bacteria;
Toxicity test;
Engineering strains
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the toxicity of genetically engineered strain R32 released to the environment.Methods Acute,chronic and cumulative toxicity test on mice,micronucleus assay of mice bone marrow cell and mice sperm malformation test were conducted to assess the toxicity of strain R32.Results R32 did not cause acute,chronic,cumulative and genetical toxic effect on mice before it absorbed heavy metal chromium.Although the mice bone marrow micronucleus frequency increased and some cumulative toxic effect emerged after R32 absorbed chromium,it did not cause acute and chronic toxicity effect on mice and mice sperm malformation rate did not increase neither.Furthermore,whether R32 absorbed heavy metal chromium or not,the effect of its secretion was not significant in all experiments compared with the control.Conclusion R32 can not cause toxic effect on mice before it absorbed chromium.Whether R32 absorbed chromium or not,the effect of its secretion was not significant in all toxicological experiments conducted in the present paper.Large content of R32 may cause some cumulative toxic effect in mice after it absorbed chromium.
